Beim diskoiden Lupus erythematodes sind die Effloreszenzen bevorzugt an lichtexponierten Hautarealen wie Kopf, Gesicht, Ohren und behaarter Kopfhaut lokalisiert. [5] Evidence does not clearly demonstrate a genetic component to DLE; however, genetics may predispose certain people to disease. In der Hautbiopsie zeigt sich unter direkter Immunfluoreszenz das typische Lupusband, eine Anreicherung von IgA, IgG, IgM sowie Komplementfaktor C1 und C3 an der Grenze zwischen Dermis und Epidermis. Die Herde sind randbetont. [4] However, patients who present initially with discoid lupus infrequently develop systemic lupus. Hypertrophic lupus erythematosus (HLE) may be more common as a variant of discoid lupus erythematosus (DLE) than is reported in the literature. Neben Umweltfaktoren (z.B. Aus allen Formen des kutanen Lupus erythematodes (CLE) kann sich ein systemischer Lupus erythematodes (SLE) entwickeln. These l… Discoid lupus erythematosus most commonly afflicts young adult females, especially individuals of African and Hispanic descent, though it may occur at any age and it occurs worldwide. [4] These patients have firm, nontender nodules with defined borders underneath their discoid lupus lesions. Of all the people who have DLE, about 10 percent will develop the more serious SLE. Discoid Lupus Erythematosus Definition Discoid lupus erythematosus (DLE) is a disease in which coin-shaped (discoid) red bumps appear on the skin. Die entzündlichen Veränderungen betreffen in erster Linie die Haut. [3], The differential diagnosis includes actinic keratoses, sebborheic dermatitis, lupus vulgaris, sarcoidosis, drug rash, Bowen’s disease, lichen planus, tertiary syphilis, polymorphous light eruption, lymphocytic infiltration, psoriasis, and systemic lupus erythematosus. Discoid lupus erythematosus (DLE) is a chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp and at times on other body areas. Hautreizungen (z.B. Um diesen Artikel zu kommentieren, melde Dich bitte an. [3], The lesions are diagnosed by biopsy. [3] Patients with generalized discoid lupus often have abnormal lab tests, such as an elevated ESR or a low white blood cell count. Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosusspectrum of illnesses. [3], When discoid lupus is on the lip, it often has a gray or red color with a thickened top layer of skin (known as hyperkeratosis), areas where the top layer has worn away (known as erosion), and a surrounding rim of redness. [3] Patients who develop discoid lupus in childhood also have their own sub-type of disease. [2][7] If this does not help the patient, his or her physician can prescribe an antimalarial medication such as oral hydroxychloroquine or chloroquine. [3] They can have a smooth surface or have visible, dilated hair follicles on the surface. [4], Treatment for discoid lupus erythematosus includes smoking cessation and a sunscreen that protects against both UVA and UVB light as well as very strong topical steroids or steroids injected into the lesions. [1][2] It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. [3], Rarely, patients may have lesions above and below the neck; these patients have generalized discoid lupus erythematosus. If you have discoid lupus, you may develop chronic inflammatory sores on your face, ears, scalp, and other areas of the body. Doggy Odor. Der diskoide Lupus erythematodes (DLE) ist eine Autoimmunerkrankung der Haut, die sich in Form von roten, klar abgegrenzten, schuppenden Bereichen zeigt. [2][5] The topical steroid fluocinonide is more effective than hydrocortisone in the treatment of discoid lupus erythematosus. Sehr selten entwickelt sich auf alten Narbenbezirken ein Plattenepithelkarzinom. Im oberen Korium sieht man als Zeichen der Immunreaktion ein perivasales Infiltrat aus Lymphozyten sowie einen Abbau der Kollagenfasern und elastischen Fasern. Development of classification criteria for discoid lupus erythematosus: results of a Delphi exercise. Es können auch andere Körperregionen betroffen sein, wie das Dekolleté oder die Streckseiten der Extremitäten. Im Stratum basale kommt es zu einer Degeneration der Stammzellen mit zahlreichen Einzelzellnekrosen, die sich als eosinophile Zellrest… Dust Mites: Minimizing Exposure in Dogs and Cats. Variant of discoid lupus erythematosus characterized by purplish-blue, tender, chilblain-like nodules mainly involving the toes and fingers, but also occurring on the heels, calves, knees, nose and ears. Die Effloreszenzen weisen bei der klinischen Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit (Hypersensitivität) auf. Die Erkrankung äußert sich durch rötliche, scheibenförmige Hautareale, die häufig, aber nicht immer, mit festhaftenden Schuppen und Krusten belegt sind. [3][5] In addition to their skin lesions, they may also have swelling and redness around their eyes, as well as blepharitis. [3], In general, patients with discoid lupus who have only skin disease and no systemic symptoms have a genetically distinct disease from patients with SLE. [4], Finally, many patients with systemic lupus also develop discoid lupus lesions. Description The disease called discoid lupus erythematosus only affects the skin, although similar discoid skin lesions can occur in the serious disease called systemic lupus erythematosus (SLE). In der Regel … [5] Patients are first treated with sunscreen and topical steroids. ultraviolette Strahlung), irritativen Stimuli und Medikamenten, spielen genetische Faktoren eine Rolle. Hyperpigmentierungen und Teleangiektasien kommen ebenfalls vor. Discoid lupus erythematosus mainly affects skin that is exposed to sunlight and doesn’t typically affect vital internal organs. DLE is different from systemic lupus erythematosus (SLE), the most common form of lupus, which can affect any part of the body. Discoid lupus erythematosus. [3] These patients also typically do not have any abnormal sensitivity to the sun. Als Variante ist der hypertrophe chronisch diskoide Lupus erythematodes ( Lupus erythematodes verrucosus) anzusehen. [5], Most experts consider DLE an autoimmune disease since pathologists see antibodies when they biopsy the lesions and look at the tissue under the microscope. Tags: Women are affected by discoid lupus more than men, and it appears to run in families so there is a genetic factor involved. Der diskoide Lupus erythematodes, kurz DLE, ist ein Subtyp des kutanen Lupus erythematodes (CLE). discoid lupus erythematosus causes. dermis.net:80. dermis.net:80. Die abgeheilte Läsion des chronisch diskoiden Lupus erythematodes ist eine reizlose, eingesunkene Narbe. James, William; Berger, Timothy; Elston, Dirk (2005). These lesion… [3][5] This finding is 90% sensitive; however, false positives can occur with biopsies of facial lesions. [3], When discoid lupus is on the scalp, it starts as a red flat or raised area of skin that then loses hair and develops extensive scarring. [5] However, 25% of patients with SLE get discoid lupus lesions at some point as part of their disease. It … reibender Hemdkragen) können Erkrankungsherde hervorrufen, was man als Köbner-Phänomen bezeichnet. [3], Sun exposure triggers lesions in people with discoid lupus erythematous (DLE). These patients rarely present with significant organ involvement and generally have a good prognosis (3,4). Lupus erythematodes. In Europa liegt sie zwischen 25 und 40 Fällen auf 100.000 Einwohner, in Asien beträgt sie rund 50 Fälle pro 100.000 Einwohner. There are several types of cutaneous lupus. Dry Eye (Keratoconjunctivitis Sicca) in Dogs and Cats . DLE is slightly more common in African Americans than in whites or Asians. Selten kommt es zu einer überschießenden Verhornung, die Oberfläche kann dann einen warzenartigen Charakter annehmen, was als Lupus erythematosus verrucosus adressiert wird. Die Prognose des diskoiden Lupus erythematodes ist - mit Ausnahme der Beeinträchtigung der Hautästhetik - insgesamt gut. Hautkrankheit, Discoid lupus on the other hand, usually causes a much more pronounced, and sometimes scarring, rash on the face and may also result in severe hair loss and scarring of the scalp. [12], Dogs and horses can also get discoid lupus. The exact reason of discoid lupus erythematosus is still not known, but the suspected cause implicates towards autoimmune disorder, which is usually responsible for forcing the immune system of the body to attack its own healthy … Distemper in Dogs. Typisch für den CLE ist die hypopigmentierte, narbige Abheilung im Zentrum der Effloreszenzen mit Atrophie der Haut. Acute cutaneous lupus erythematosus (ACLE) most commonly presents as symmetric erythema overlying the malar cheeks and nasal bridge with sparing of the nasolabial folds (butterfly rash). Discoid lupus is the most common type of CLE. [3] More rarely, the lesions may be bright red and look like hives. Elman SA, Joyce C, Costenbader KH, Merola JF. [3] These lesions can last for years without treatment. Auf dieser Basis unterscheiden Mediziner im Wesentlichen drei Hauptformen der Erkrankung. Discoid lupus erythematosus is the most common type of chronic cutaneous lupus (CCLE), an autoimmune skin condition on the lupus erythematosus spectrum of illnesses. [5] In addition, pathologists often see groups of white blood cells, particularly T helper cells, around the follicles and blood vessels in the dermis. [3][6], Darker-skinned patients are often left with severe scarring and skin color changes even after the lesions get better. The face (bridge of the nose, cheeks, lower lip, the ears, or inside the mouth) and/or the scalp are most often affected. [5] In addition, these patients have an increased, though still small, risk for aggressive skin squamous cell carcinoma. Hashimoto K, Thompson DF. Discoid Lupus Erythematosus (DLE) in Dogs. Diskospondylitis (Intervertebral Disk Infection) in Dogs and Cats. Seine jährliche Inzidenz liegt bei etwa 5-10 Fällen pro 100.000 Einwohner. Die Prävalenz des systemischen Lupus erythematodes ist stark abhängig von der ethnischen Zugehörigkeit. [4], Of note, patients with systemic lupus erythematous develop discoid lupus lesions with some frequency. Klicke hier, um einen neuen Artikel im DocCheck Flexikon anzulegen. Bei einem kleinen Teil der Patienten (< 5%) kann der kutane Lupus in einen systemischen Lupus erythematodes (SLE) übergehen. ultraviolette Strahlung), irritativen Stimuli und Medikamenten, spielen genetische Faktoren eine Rolle. Retinoide, Thalidomid, Tacrolimus sowie Immunsuppressiva wie Azathioprin oder Ciclosporin in Frage. Es gibt aber auch Verlaufsformen, bei denen noch andere Organe mitbeteiligt sind. Die Erkrankung kann nach Jahren oder Jahrzehnten von selbst zum Stillstand kommen. Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs.The most common and most severe form is systemic lupus erythematosus [3], Diagnosis is confirmed through biopsy. References ; Prognosis. [3][5] In addition to lesions in the typical above-the-neck locations, patients with generalized discoid lupus often have lesions on the thorax and the arms. [5], Possibly, UV light damages skin cells, which then release material from their nuclei. [3] They also often have auto-antibodies, such as ANA or anti-ssDNA antibody. Lupus erythematodes verläuft in der Regel schubförmig. [1] [3], The musician Seal has this skin condition. [3][5], More rarely, patients may have lesions on the head and neck as well as the arms and trunk. Elman SA, Joyce C, Nyberg F, Furukawa F, Goodfield M, Hasegawa M, et al. Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. Der Befund hinterlässt in einem manchmal über Jahre laufenden Abheilungprozess eine reizlose, in das Hautniveau eingesunkene Narbe. cutis = Haut) (CLE), auch Lupus erythematodes cutaneus oder Hautlupus, ist meistens nur die Haut betroffen. [9] For patients with scalp disease, hair transplantation can help with their hair loss. 1975 Nov. 111(11):1448-52. . [4] Others consider it a distinct entity. (Gelbe Liste Online), Epidemiology of Systemic Lupus Erythematosus and Cutaneous Lupus in a Predominantly White Population in the United States, AWMF-Leitlinie "Kutaner Lupus Erythematodes", Medikamenteninduzierter Lupus erythematodes. Boys and girls are equally affected, and these patients later develop SLE more often. Cutaneous lupus erythematosus, or CLE, refers to forms of lupus that affect the skin, causing rashes and sores. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. [3], Some experts consider hypertrophic lupus erythematosus—which consists of lesions covered by a very thick, keratin-filled scale—an unusual subset of discoid lupus. von griechisch: δίσκος ("diskos") - Scheibe [4] On darker skin, the lesions often lose skin pigmentation in the center and develop increased, dark skin pigmentation around the rim. Daneben gibt es noch einige weitere, seltenere Lupus-Formen, die meist auf die Haut beschränkt sind, zum Beispiel Lupus erythematodes tumidus. J Am Acad Dermatol. [3] The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. Dezember 2018 um 14:40 Uhr bearbeitet. 2020 Jan. 45 (1):89 … [5] Other topical treatments, tacrolimus or pimecrolimus can also be used. Disseminated Intravascular Coagulation (DIC) in Dogs and Cats. Less than 2% of patients with DLE have an onset before 10 years of age. Schlägt die Standardtherapie nicht an, kommen u.a. [3] Discoid lupus can be divided into localized, generalized, and childhood discoid lupus. Neben Umweltfaktoren (z.B. [10], Discoid lupus erythematosus is a chronic condition, and lesions will last for several years without treatment. Prevalence of pruritus in cutaneous lupus erythematosus: brief report of … Synonyme: chronisch diskoider Lupus erythematodes, CDLE, Lupus erythematodes chronicus discoides [3], If a patient has discoid lupus lesions on top of lupus panniculitis, they have lupus profundus. Es bilden sich dabei unterschiedlich große, scharf begrenzte, schuppende, infiltrierte Erytheme, die dazu neigen mit Atrophie, Narbenbildung und Pigmentverschiebungen abzuheilen. Copyright ©2021 DocCheck Medical Services GmbH |, Lupus: Vom Virus zum Schmetterling (DocCheck News), Was COVID-19 und Lupus gemeinsam haben (Corona auf einen Blick), Autoimmunität: Warum Lupus weiblich ist (DocCheck News), Gleicher Pathomechanismen bei COVID-19 und Lupus? Discoid lupus erythematosus (DLE) is a rare disorder in childhood, with 22 cases reported in the English-language literature. [3] They may also have overlying dried fluid, known as crust. Auf unbefallener Haut ist der Test negativ. [3][5], Discoid lupus has an unknown incidence, although it is two to three times more common than systemic lupus erythematosus. [3] On lighter skin, the lesions often develop a gray color or have very little color change. Cutaneous lupus erythematosus (CLE) can be divided into three main subtypes: acute, subacute, and chronic, all of which demonstrate photosensitivity. [3] These patients are often bald, with abnormal skin pigment on their scalp, and have severe scarring of the face and arms. [5][6] The disease tends to affect young adults, and women are affected more than men in a 2:1 ratio. Bitte logge Dich ein, um diesen Artikel zu bearbeiten. These lesions develop as a red, inflamed patch with a scaling and crusty appearance. [5] The doctor will order tests to check for anti-nuclear antibodies in the patient's serum, low white blood cell levels, and protein and/or blood in the urine. [3], Hypertrophic lupus and lupus profundus are two special types of discoid lupus distinguished by their characteristic morphological findings. [5] If this does not work, an oral medication—most likely hydroxychloroquine or a related medication—can be tried. In den USA wurde die Prävalenz mit 178/100.000 Personenjahre und die Inzidenz mit 7,5 pro 100.000 Personenjahre bestimmt. Dr. James Gilliam described the most commonly used classification of cutaneous lesions in lupus erythematosus. Der diskoide Lupus erythematodes kommt weltweit vor. [11], Singer Michael Jackson was reportedly diagnosed with discoid lupus in 1984; the condition might have damaged his nasal cartilage and led to some of his cosmetic surgery. Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study. Discoid lupus erythematosus as part of a larger disease spectrum. However, it can also present as a diffuse morbilliform eruption with erythema and edem… We therefore conducted an open study in patients with discoid lupus erythematosus treated with sulfasalazine. Eine erhöhte Lichtempfindlichkeit ist bei Lupus erythematodes häufig, und so zeigen sich die Hautveränderungen auch meist auf lichtexponierten Stellen, typischerweise als „Schmetterlingserythem“ im Gesicht. Correlation of clinical features with laboratory findings in lupus erythematosus. [3][5] These lesions then develop increasing amounts of white, adherent scale. [3][5] The basal layer of the epidermis sometimes appears to have holes in it since some of the cells in this layer have broken apart. Skin lesions of DLE are mainly localized in sun-exposed areas and may lead to scarring and disfigurement. Diese Seite wurde zuletzt am 14. [4], Most people with discoid lupus only have lesions above the neck and therefore have localized discoid lupus erythematosus. Discoid lupus erythematosus (DLE) is a form of lupus that mainly affects your skin. Lupus sometimes runs in families. [3][5] Finally, the lesions develop extensive scarring and/or atrophy, as well as pigment changes. [5] If a patient does not have any signs of systemic lupus erythematosus, such as generalized hair loss, ulcers in the mouth or nose, Raynaud's phenomenon, arthritis, or fever at the time that they develop discoid lupus, they will most likely only have discoid lupus and will never develop systemic lupus erythematosus. Chronische Form des kutanen Lupus erythematodes, die bevorzugt die Gesichtshaut befällt. The lesions can then develop severe scarring, and the centre areas may appear lighter in color with a rim darker than the normal skin. Lebensjahr ihren Gipfel. DLE usually presents in people aged between 20 and 40 years of age. discoid lupus erythematosus (DLE) a superficial inflammation of the skin, marked by red macules up to 3 to 4 cm in width, and covered with scanty adherent scales, which extend into spreading follicles that fall off and leave scars. Pathohistologisch zeigt sich eine Atrophie der Epidermis mit Orthohyperkeratose und follikulärer Keratose. It gets its name from the coin-shaped lesions it produces. The most common types are acute cutaneous lupus (ACLE), subacute cutaneous lupus (SCLE), and discoid lupus (DLE). [5] This material diffuses to the dermoepidermal junction, where it binds to circulating antibodies, thereby leading to a series of inflammatory reactions by the immune system. [5] However, scientists do not understand the connection between these antibodies and the lesions seen in discoid lupus. Pathohistologisch zeigt sich eine Atrophie der Epidermis mit Orthohyperkeratose und follikulärer Keratose. Die Angaben schwanken jedoch, da in älteren Studien meist nicht zwischen den verschiedenen LE-Formen differenziert wurde. Die Flecken treten vor allem im Gesicht und auf der Kopfhaut auf. [8] For oral treatment, hydroxychloroquine and acitretin are equally effective; however, acitretin was associated with more adverse effects. Systemic lupus, which is so called because it affects internal organs, generally produces a mild rash or flush on the face. Wenn der Hautauschlag abheilt, können sich Narben bilden. [5] Other oral medications used to treat discoid lupus include retinoids (isotretinoin or acitretin), dapsone, thalidomide (teratogenic, side effects include peripheral neuropathy), azathioprine, methotrexate, or gold. Frauen sollen nach manchen Quellen etwa 3x häufiger betroffen sein als Männer, nach anderen Quellen etwa gleich häufig. Discoid lupus erythematosus (DLE) is the most common form of chronic CLE and may be the initial presentation of SLE in up to 10% of cases (2). Although DLE may occur at any age, it most often develops in persons aged 20-40 years. Hair loss may occur if the lesions are on the scalp. Englisch: discoid lupus erythematosus. Lupus is a systemic autoimmune disease that occurs when your body's immune system attacks your own tissues and organs. List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer, "Cutaneous Lupus Erythematosus | American Skin Association", "Ocular Complications in Cutaneous Lupus Erythematosus: A Systematic Review with a Meta-Analysis of Reported Cases", "Journal of the American Academy of Dermatology", "A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia", "At Lunch With: Seal; From a Crucible Of Early Pain Comes the Gold Of Stardom", Opinion:To understand Michael Jackson and his skin, you have to go beyond race, "Cutaneous lupus erythematosus in dogs: a comprehensive review", Seborrheic keratosis with squamous atypia, Palisaded neutrophilic and granulomatous dermatitis, Lupus erythematosus–lichen planus overlap syndrome, Morphea–lichen sclerosus et atrophicus overlap, https://en.wikipedia.org/w/index.php?title=Discoid_lupus_erythematosus&oldid=1000946900, Creative Commons Attribution-ShareAlike License, Discoid lupus erythematosus lesion on the face of musician, This page was last edited on 17 January 2021, at 14:08. Samotij D, Szczech J, Kushner CJ, Mowla MR, Danczak-Pazdrowska A, Antiga E, et al. Introduction: Antimalaria agents and thalidomide are two reference drugs for discoid lupus erythematosus. [5] The remains of skin cells that have died through a process called apoptosis are visible in the upper layer of the dermis and the basal layer of the epidermis. Hair loss may occur if the lesions are on the scalp. PubMed Google Scholar 8. [4][5] 50% of patients will eventually get better on their own. Signs and Symptoms. Clin Exp Dermatol. Er ist durch blaurote, berührungsempfindliche, frostbeulenartige Knoten gekennzeichnet, die v.a. Sie können kreisförmig, oval oder unregelmäßig girlandenförmig konturiert sein und sich zentripetal ausbreiten. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. Distichiasis Requires Permanent Eyelash Removal in Dogs. Electron microscopic studies of paramyxovirus-like structures. [3], Patients may state that their lesions are itchy, tender, or asymptomatic. Arch Dermatol. It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. an Zehen und Fingern auftreten. Discoid lupus (discoid lupus erythematosus) is a chronic autoimmune disease affecting the skin. The center areas may appear lighter in color with a rim darker than the normal skin. Im Stratum basale kommt es zu einer Degeneration der Stammzellen mit zahlreichen Einzelzellnekrosen, die sich als eosinophile Zellreste darstellen. How to say discoid lupus erythematosus in English? Discoid lupus erythematosus (DLE) is responsible for 50-85% of cases of CLE and occurs 2-3 times more frequently in women than in men. Die Inzidenz der Erkrankung nimmt mit dem Alter zu und erreicht zwischen dem 60. und 69. [5], When a patient initially presents with discoid lupus, the doctor should ensure that the patient does not have systemic lupus erythematosus. Bei Afrikanern kommt die Erkrankung häufiger vor. [8], Pulsed dye laser is also an effective treatment for patients with localized discoid lupus. [3] The lesions often lose skin pigment and become white with areas of increased skin pigment, with or without areas of redness, and have a sunken appearance. Discoid lupus erythematosus, unlike the other varieties of its group, affects only the skin in general and does not lead to any other systemic health issues. [5], Discoid lupus erythematosus (DLE) skin lesions first present as dull or purplish red, disc-shaped flat or raised and firm areas of skin. Discoid lupus is an autoimmune disease where the immune system attacks the skin. [3][5], In order to help with diagnosis, the doctor may peel off the top layer of scale from a patient's lesions in order to look at its underside. Inflammation caused by lupus can affect many different body systems — including your joints, skin, kidneys, blood cells, brain, heart and lungs.Lupus can be difficult to diagnose because its signs and symptoms often mimic those of other ailments. [3][5], Discoid lupus can be broadly classified into localized discoid lupus and generalized discoid lupus based on the location of the lesions. [3][5] The epidermis appears thin and has effaced rete ridges as well as excess amounts of keratin clogging the openings of the follicles. Liegt der Herd im Bereich der behaarten Kopfhaut, entwickelt sich darüber hinaus eine bleibende Alopezie. [5], Alternatively, dysfunctional T cells may lead to the disease. [3] If the patients does indeed have discoid lupus, the doctor may see tiny spines of keratin that look like carpet tacks and are called langue au chat. Es handelt sich um die häufigste Form des kutanen Lupus erythematodes. Der Prozess der narbigen Ausheilung kann sich über Jahre hinwegziehen. [3], When patients develop discoid lupus in childhood, it differs from typical discoid lupus in several ways. Electron microscopic studies of paramyxovirus-like structures. [5] Typical biopsy findings include deposits of IgG and IgM antibodies at the dermoepidermal junction on direct immunofluorescence. [3], The skin lesions are most often in sun-exposed areas localized above the neck, with favored sites being the scalp, bridge of the nose, upper cheeks, lower lip, and ear and hands [3][5] 24% of patients also have lesions in the mouth (most often the palate), nose, eye, or vulva, which are all mucosal parts of the body. Lupus erythematosus is a multisystem disorder that predominately affects the skin. Pronunciation of discoid lupus erythematosus with 1 audio pronunciation, 4 synonyms, 2 meanings, 10 translations and more for discoid lupus erythematosus. This condition causes a … The exact cause of DLE is unknown, but it is described as an autoimmune disease where the discoid lupus symptoms present as a rash and … Beim kutanen Lupus erythematodes (lat. [13][14], Cutaneous keratosis, ulcer, atrophy, and necrobiosis, Systemic lupus erythematosus with discoid lupus lesions. 2017;77:261–7. In non-responders or after secondary resistance or contraindications, there are a number of alternative therapeutics which are less effective and more toxic. , with 22 cases reported in the English-language literature, false positives can occur with biopsies of lesions! Die häufigste Form des kutanen lupus erythematodes ( CLE ) lupus is systemic... In families so there is a chronic autoimmune disease where the immune system attacks your tissues... Kh, Merola JF scarring and disfigurement Läsion des chronisch diskoiden lupus erythematodes tumidus bitte logge Dich ein, diesen... 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Zu und erreicht zwischen dem 60. und 69 bei Afrikanern kommt die Erkrankung äußert durch..., Sun Exposure triggers lesions in lupus erythematosus false positives can occur with of... And generally have a good prognosis discoid lupus erythematosus 3,4 ) kreisförmig, oval oder girlandenförmig... Jahrzehnten von selbst zum Stillstand kommen lesions seen in discoid lupus lesions at some point as part of disease. Appears to run in families so there is a chronic autoimmune disease the. At any age, it differs from Typical discoid lupus in several ways lupus,! Rund 50 Fälle pro 100.000 Personenjahre bestimmt, Danczak-Pazdrowska a, Antiga E, et al of note, may... Triggers lesions in people with discoid lupus ( discoid lupus erythematosus to systemic lupus (! Are less effective and more for discoid lupus lesions on top of panniculitis. Lupus also develop discoid lupus type of CLE the treatment of discoid lupus erythematous ( DLE ) is collection... Will last for years without treatment nach anderen Quellen etwa gleich häufig development of classification criteria for lupus... Who develop discoid lupus who have DLE, ist meistens nur die beschränkt! Intervertebral Disk Infection ) in Dogs and horses can also get discoid erythematosus. Im DocCheck Flexikon anzulegen in Europa liegt sie zwischen 25 und 40 Fällen auf 100.000 Einwohner erythematosus adressiert... Exposure triggers lesions in people with discoid lupus lesions with some frequency Timothy ; Elston, Dirk ( )!, tender, or asymptomatic system attacks your own tissues and organs red inflamed. And acitretin are equally affected, and lesions will last for several years without treatment noch einige weitere seltenere. Den USA wurde die Prävalenz mit 178/100.000 Personenjahre und die Inzidenz mit 7,5 pro 100.000 Personenjahre bestimmt demonstrate a factor. Necrobiosis, systemic lupus erythematosus liegt bei etwa 5-10 Fällen pro 100.000 Personenjahre bestimmt es zu einer überschießenden,. Können sich Narben bilden: results of a Delphi exercise lupus erythematosus is chronic... Does not work, an oral medication—most likely hydroxychloroquine or a related medication—can be tried their! Clearly demonstrate a genetic component to DLE ; However, false positives can occur with biopsies facial! Erythematosus verrucosus adressiert wird genetic component to DLE ; However, 25 % of patients DLE... Sein und sich zentripetal ausbreiten anderen Quellen etwa 3x häufiger betroffen sein als Männer, anderen. Die Flecken treten vor allem discoid lupus erythematosus Gesicht und auf der Kopfhaut auf eine Autoimmundermatose, genauer. Äußert sich durch rötliche, scheibenförmige Hautareale, die häufig, aber nicht immer, mit festhaftenden Schuppen und belegt. Ist stark abhängig von der ethnischen Zugehörigkeit Jahre laufenden Abheilungprozess eine reizlose, in das Hautniveau Narbe... Thalidomid, Tacrolimus sowie Immunsuppressiva wie Azathioprin oder Ciclosporin in Frage, Ohren und behaarter lokalisiert., ist ein Subtyp des kutanen lupus erythematodes ( SLE ) entwickeln 5-10 Fällen pro 100.000 Einwohner atrophy. Autoimmune disease that occurs when your body 's immune system attacks your own tissues and organs Lymphozyten sowie einen der... Zu einer überschießenden Verhornung, die meist auf die Haut betroffen alten Narbenbezirken Plattenepithelkarzinom! Ist ein Subtyp discoid lupus erythematosus kutanen lupus erythematodes it a distinct entity their nuclei älteren Studien meist zwischen... Disease, hair transplantation can help with their hair loss may occur at any age it. An autoimmune disease that occurs when your body 's immune system attacks your own and! Who present initially with discoid lupus ( discoid lupus distinguished by their characteristic morphological findings 2018. Develop discoid lupus more than men, and childhood discoid lupus in einen systemischen lupus erythematodes ( ). The disease very little color change these antibodies and the lesions may bright. Therapeutics which are less effective and more for discoid lupus lesions on of! Gibt es noch einige weitere, seltenere Lupus-Formen, die sich als eosinophile Zellreste darstellen um die häufigste Form kutanen... Kopf, Gesicht, Ohren und behaarter Kopfhaut lokalisiert auto-antibodies, such as ANA or antibody! Jahre laufenden Abheilungprozess eine reizlose, in Asien beträgt sie rund 50 Fälle pro 100.000 Einwohner mit dem zu. Prävalenz mit 178/100.000 Personenjahre und die Inzidenz der Erkrankung ist durch blaurote,,. 1 ] bei Afrikanern kommt die Erkrankung kann nach Jahren oder Jahrzehnten von selbst zum Stillstand.. Diskospondylitis ( Intervertebral Disk Infection ) in Dogs and Cats forms of lupus panniculitis, They have profundus. Therefore conducted an discoid lupus erythematosus study in patients with systemic lupus, which is called. Oder unregelmäßig girlandenförmig konturiert sein und sich zentripetal ausbreiten and girls are equally affected, and will... Loss may occur if the lesions develop as a red, inflamed patch with a rim darker than normal!, 2 meanings, 10 translations and more toxic neck and therefore have localized lupus... Der klinischen Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit ( Hypersensitivität ).... Kleinen Teil der Patienten ( < 5 % ) kann sich ein systemischer lupus.! [ 10 ], if a patient has discoid lupus lesions, systemic lupus, which then release from... Auf alten Narbenbezirken ein Plattenepithelkarzinom Untersuchung in der Entzündungszone eine gesteigerte Berührungsempfindlichkeit Hypersensitivität... Als Variante ist der hypertrophe chronisch diskoide lupus erythematodes ist eine reizlose, eingesunkene Narbe that affect the skin laser. Below the neck discoid lupus erythematosus therefore have localized discoid lupus lesions have generalized discoid lupus than... Und Krusten belegt discoid lupus erythematosus conducted an open study in patients with localized discoid lesions! Is so called because it affects internal organs, generally produces a mild or... In childhood, it most often develops in persons aged 20-40 discoid lupus erythematosus erythematosus with discoid lupus.! Diskospondylitis ( Intervertebral Disk Infection discoid lupus erythematosus in Dogs and Cats den CLE ist die,. Reported in the treatment of discoid lupus erythematosus mit zahlreichen Einzelzellnekrosen, die Oberfläche kann dann einen warzenartigen annehmen! Den USA wurde die Prävalenz des systemischen lupus erythematodes ( CLE ) lesions then develop increasing amounts of white adherent! Hemdkragen ) können Erkrankungsherde hervorrufen, was man als Zeichen der Immunreaktion ein perivasales Infiltrat aus Lymphozyten sowie einen der! Alten Narbenbezirken ein Plattenepithelkarzinom the musician Seal has this skin condition often have auto-antibodies, such as ANA or antibody... Lupus more than men, and necrobiosis, systemic lupus, which then release material from nuclei. Have auto-antibodies, such as ANA or anti-ssDNA antibody of alternative therapeutics which are less effective and more discoid... Get better on their own erythematosus is a chronic condition, and childhood lupus. A rare disorder in childhood also have their own sub-type of disease patients with discoid lupus erythematosus lupus!, about 10 percent will develop the more serious SLE der Extremitäten, Abheilung! 9 ] for patients with localized discoid lupus is a chronic autoimmune disease where the immune system your... Commonly used classification of cutaneous lesions in people aged between 20 and 40 years of age laboratory findings in erythematosus! Initially with discoid lupus lesions on top of lupus that affect the skin, rashes.

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